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More information: Dr. Redfield will present the study \"Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (RELAX) Trial\" on Monday, March 11 at 11:30 a.m., in Moscone Center, South, Esplanade Ballroom. The study was a double-blind, placebo-controlled, randomized clinical trial. While Dr. Redfield does not believe a larger trial of PDE-5 inhibitors is warranted in the general population of patients with diastolic heart failure, she said further research is needed to ascertain their potential benefits with certain subgroups of patients. Although sildenafil and other PDE-5 inhibitors are not labeled for heart failure, it is possible that some clinicians may be prescribing these drugs for their heart failure patients based on the results of preliminary studies, which suggest a benefit. 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